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The exact cause of trigeminal neuralgia is still unknown, but some factors seem to increase the risk of developing this condition

Zacharias et al

Diabetes Care 39, 801807 (2016)

Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))